Exosomes From Adipose-Derived Mesenchymal Stem Cells: A New Prospective Therapy of Diabetic Foot Ulcer.
Zhang R., Song Z., Zhang J., Zhang W., Li L., Mou F.
Narrative Review on Diabetic Foot, Chronic Wound, published in Biomed Res Int (2026) — summary generated from the PubMed abstract.
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Biomed Res Int (2026)
- Country
- United States
- Reported sample size
- —
- PMID
- 42274279
- DOI
- 10.1155/bmri/6652338
Abstract (original English)
Diabetic foot ulcer (DFU) is one of the most severe complications of diabetes, characterized by high rates of morbidity, disability, and mortality. Current treatment modalities for DFU primarily include surgical debridement, negative-pressure wound therapy, and anti-infection measures. However, these approaches are limited by prolonged treatment duration, high costs, and suboptimal therapeutic outcomes. Adipose-derived mesenchymal stem cells (ADMSCs) have garnered significant attention in wound repair and tissue regeneration due to their ability to secrete a variety of cytokines involved in the healing process. Exosomes, as key mediators of the paracrine effects underlying the therapeutic benefits of ADMSCs, are emerging as promising agents for wound repair. As a novel therapeutic strategy, exosomes have been increasingly investigated for the treatment of DFU. In this review, we summarize the applications and therapeutic potential of ADMSC-exosomes in DFU, aiming to provide a valuable reference for its clinical management.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
There is currently not enough data to draw conclusions about benefit or risk for this topic.
How we grade evidenceRelated research
- Level AMeta-analysis
Therapeutic Effect of Stem Cells from Different Sources on Diabetic Foot Ulcers: Systematic Review and Network Meta-Analysis.
Meta-analysis on Ankle Injury, Diabetic Foot, Chronic Wound, published in Int J Low Extrem Wounds (2026) — summary generated from the PubMed abstract.
- 2026
Int J Low Extrem Wounds - Level AMeta-analysis
Efficacy of Stem Cell-Derived Exosomes in Promoting Diabetic Foot Ulcer Healing: A Meta-Analysis of Preclinical Animal Studies.
Meta-analysis on Diabetic Foot, Chronic Wound, published in J Diabetes Res (2026) — summary generated from the PubMed abstract.
- 2026
J Diabetes Res - Level AMeta-analysis
Role of Adipose Derived Stem Cells in Patients with Diabetic Foot Ulcers: Systematic Review and Meta-Analysis of Randomised Controlled Trials.
Meta-analysis with a reported sample of 81 on Diabetic Foot, Chronic Wound, published in Int J Low Extrem Wounds (2025) — summary generated from the PubMed abstract.
- 2025
- n = 81
Int J Low Extrem Wounds - Level ASystematic Review
Therapeutic potential of adipose-derived stem cells for diabetic foot ulcers: a systematic review and meta-analysis.
Systematic Review on Diabetic Foot, Chronic Wound, published in Diabetol Metab Syndr (2025) — summary generated from the PubMed abstract.
- 2025
Diabetol Metab Syndr - Level AMeta-analysis
A meta-analysis on application and prospect of cell therapy in the treatment of diabetes mellitus.
Meta-analysis on Diabetic Foot, Autoimmune Research, published in Stem Cell Res Ther (2025) — summary generated from the PubMed abstract.
- 2025
Stem Cell Res Ther - Level ASystematic Review
Effects of Nanofat in Plastic and Reconstructive Surgery: A Systematic Review.
Systematic Review with a reported sample of 253 on Diabetic Foot, Chronic Wound, Scar, Skin Aging, published in Plast Reconstr Surg (2024) — summary generated from the PubMed abstract.
- 2024
- n = 253
Plast Reconstr Surg