Exosomes in Aesthetic Medicine: An Overview.

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The use of exosomes in regenerative aesthetics represents a conceptual shift. Although stem cells operate using an engraftment and differentiation method, exosomes mediate therapeutic effects through transfer of bioactive molecules that orchestrate regenerative cascades. These tiny particles have evolved from their initial characterization as cellular waste repositories to critical mediators of physiological processes. Laboratory research and clinical trials position exosomes as tailored biological messengers with tissue-specific tropism and immunomodulatory capabilities. Sourcing diversity, ranging from mesenchymal stem cells to immune cells and platelets, imparts distinct molecular signatures that determine therapeutic potential. Contemporary isolation techniques have progressed from ultracentrifugation to more sophisticated approaches yielding variable purity profiles. Regulatory frameworks span Section 351 of the Public Health Service Act governing minimally manipulated preparations, Section 361 therapeutics with specific drug indications, and Federal Food, Drug, and Cosmetic Act-regulated topical formulations, with international approaches varying significantly across jurisdictions. Clinical applications include photoaging remediation, scar remodeling, hair follicle regeneration, wound healing, postprocedure recovery and adipose tissue volumization, with mechanisms encompa

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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