From Fat to Healing: How Adipose-Derived Stem Cells Are Changing the Game for Diabetic Foot Ulcers-A Perspective.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background and aim Diabetic foot ulcers (DFUs) pose a significant challenge in the management of chronic wounds, characterized by a high risk of infection and severe complications, including potential limb amputation. The limitations of conventional treatments have sparked interest in regenerative therapies, particularly the use of adipose-derived stem cells (ADSCs). which possess significant potential across various medical fields for enhancing tissue repair and modulating immune responses. This perspective critically evaluates the potential of ADSCs for treating DFUs while exploring their broader implications in regenerative medicine. Methods This perspective incorporates insights from a comprehensive literature review, with searches conducted on platforms such as Google Scholar, PubMed, and Scopus. The selected studies focus on the regenerative efficacy, safety, and clinical applications of ADSCs in wound healing, emphasizing rigorous methodologies that support reliable conclusions. Results ADSCs exhibit significant promise in promoting tissue regeneration, stimulating angiogenesis, and modulating immune function-mechanisms that are beneficial not only for patients with DFUs but also for those with other chronic and non-healing wounds. Nevertheless, challenges persist, including the risk of tumorigenesis, particularly in patients with a history of cancer, as well as variabil

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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