[Morphological characteristic of wound healing process in patients with diabetic purulent-necrotic foot lesion treated with oxytocin].

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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• Level B · Emerging clinical evidence with positive signals
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• Emerging · Emerging topic under active research

Abstract (original English)

Wound healing was studied in 90 patients with "diabetic foot" receiving complex treatment which included oxytocin (40 patients) or did not use it (50 patients). Intraarterial injection or local application of oxytocin resulted in significant differences of wound process characteristics as compared with those ones in control group. The necrobiotic and necrotic changes in the tissues of skin, subcutaneous adipose tissue and skeletal muscles, located within the purulent-necrotic foci, were less expressed. The number of sludged capillaries, as well as of arterioles and venules with the signs of microthrombosis, was significantly decreased. Simultaneously, the regenerative potential of endotheliocytes, fibroblasts and adventitial cells was increased, showing a significant stimulation of their DNA-synthesizing capacity. The histological findings obtained indicate that the introduction of oxytocin in complex treatment activates the processes of vasculogenesis, proliferation of endotheliocytes anf histiocytes, that, in turn, results in the effective clearance of the wound and optimal granulation tissue formation.

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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