SVF
Level A· Stronger Clinical EvidenceSystematic Review

Regenerative Medicine for Atrophic Scars: A Systematic Review of Extracellular Vesicles, Conditioned Media, Stromal Vascular Fraction, and Mesenchymal Stem Cells.

Jafarzadeh A., Hoseini SS., Behrangi E., Roohaninasab M., Goodarzi A.

Systematic Review with a reported sample of 177 on Chronic Wound, Scar, published in Aesthetic Plast Surg (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
Aesthetic Plast Surg (2026)
Country
United States
Reported sample size
177
PMID
41099835
DOI
10.1007/s00266-025-05284-y

Abstract (original English)

Atrophic scars, caused by insufficient collagen deposition and ECM production during wound healing, significantly affect patients' quality of life. Conventional treatments often fail to achieve complete skin regeneration, prompting interest in regenerative medicine. This review evaluates the efficacy and safety of emerging regenerative therapies, including extracellular vesicles, conditioned media, stromal vascular fraction, and mesenchymal stem cells, in improving atrophic scars. A systematic search was conducted on PubMed, Scopus, and Web of Science up to November 23, 2024. Relevant keywords, including "conditioned media," "Secretome," "extracellular vesicles," "atrophic scar," "rejuvenation," and "lightening," were used to identify studies. Articles meeting inclusion criteria underwent data extraction focusing on study design, population characteristics (mean and range), intervention details (including duration), comparison groups, clinical outcomes with statistical results, and reported adverse effects, ensuring comprehensive analysis and adherence to PRISMA guidelines. Out of 186 initially identified articles, 11 studies involving 177 participants (89 females, 59 males, and 29 undefined, mean age 31.52 years) were reviewed, focusing on treatments for acne scars (82%) and striae distensae (18%). These studies evaluated stromal vascular fraction (SVF), cell-conditioned mediu

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
HumansExtracellular VesiclesCulture Media, ConditionedRegenerative MedicineCicatrixMesenchymal Stem CellsMesenchymal Stem Cell TransplantationAtrophyAdultWound Healing
Chronic WoundScar
View on PubMedDOI

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