Regenerative Medicine for Atrophic Scars: A Systematic Review of Extracellular Vesicles, Conditioned Media, Stromal Vascular Fraction, and Mesenchymal Stem Cells.

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Introduction Atrophic scars, caused by insufficient collagen deposition and ECM production during wound healing, significantly affect patients' quality of life. Conventional treatments often fail to achieve complete skin regeneration, prompting interest in regenerative medicine. This review evaluates the efficacy and safety of emerging regenerative therapies, including extracellular vesicles, conditioned media, stromal vascular fraction, and mesenchymal stem cells, in improving atrophic scars. Method A systematic search was conducted on PubMed, Scopus, and Web of Science up to November 23, 2024. Relevant keywords, including "conditioned media," "Secretome," "extracellular vesicles," "atrophic scar," "rejuvenation," and "lightening," were used to identify studies. Articles meeting inclusion criteria underwent data extraction focusing on study design, population characteristics (mean and range), intervention details (including duration), comparison groups, clinical outcomes with statistical results, and reported adverse effects, ensuring comprehensive analysis and adherence to PRISMA guidelines. Result Out of 186 initially identified articles, 11 studies involving 177 participants (89 females, 59 males, and 29 undefined, mean age 31.52 years) were reviewed, focusing on treatments for acne scars (82%) and striae distensae (18%). These studies evaluated stromal vascular fraction (S

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.