SVF
Level C· Early human research exploring benefitsProspective StudyPubMed

Regenerative Nanofat Membrane Development Process.

Fakih-Gomez N., Manay R., Nazari S., Martins L., Muñoz-Gonzalez C.

Prospective Study with a reported sample of 172 on Diabetic Foot, Chronic Wound, published in Aesthetic Plast Surg (2024) — summary generated from the PubMed abstract.

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Level C· Early human research exploring benefitsEvidence level of this study

Early human evidence such as case series or small samples is exploring possible benefits.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Prospective Study
Journal
Aesthetic Plast Surg (2024)
Country
United States
Reported sample size
172
Source database
PubMed
PMID
39663222
DOI
10.1007/s00266-024-04562-5
Citations
3

Abstract (original English)

Introduction Chronic wounds present a significant challenge in clinical practice due to complications like infections and prolonged healing times. Conventional treatments often fall short, necessitating advancements in wound healing strategies. This article introduces a novel approach using a combination of adipose-derived stem cells (ADSCs) from fat and growth factors from platelet-rich fibrin (PRF) to enhance wound healing outcomes. Methods The Fakih-Manay fat membrane device was utilized to prepare fat membranes. Microfat was harvested and emulsified to produce nanofat, which was then combined with PRF to create a Nanofat-PRF membrane. The resulting membrane was uniform, versatile, and suture-friendly, making it ideal for various medical and surgical applications. Results Between April 2019 and April 2024, 172 patients received treatment using a nanofat membrane. The membrane showed significant improvement in wound healing in various cases including diabetic foot ulcers, cleft palate surgeries, facial dermabrasion, skin necrosis, revision rhinoplasties, and post-cosmetic surgery complications. Postoperative follow-up after healing ranged from 1 to 16 months, showing high patient satisfaction and significant improvements in wound healing and no reported complications. Conclusion The nanofat membrane presents a versatile and innovative approach to enhancing healing across a br

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

How we grade evidence
HumansWound HealingFemaleMaleMiddle AgedAdultAdipose TissuePlatelet-Rich FibrinTreatment OutcomeAged
Face & SkinAnkle & FootDiabetic FootChronic Wound
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