SVF
Level C· Early Human ResearchProspective Study

Regenerative Nanofat Membrane Development Process.

Fakih-Gomez N., Manay R., Nazari S., Martins L., Muñoz-Gonzalez C.

Prospective Study with a reported sample of 172 on Diabetic Foot, Chronic Wound, published in Aesthetic Plast Surg (2025) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Prospective Study
Journal
Aesthetic Plast Surg (2025)
Country
United States
Reported sample size
172
PMID
39663222
DOI
10.1007/s00266-024-04562-5

Abstract (original English)

Chronic wounds present a significant challenge in clinical practice due to complications like infections and prolonged healing times. Conventional treatments often fall short, necessitating advancements in wound healing strategies. This article introduces a novel approach using a combination of adipose-derived stem cells (ADSCs) from fat and growth factors from platelet-rich fibrin (PRF) to enhance wound healing outcomes. The Fakih-Manay fat membrane device was utilized to prepare fat membranes. Microfat was harvested and emulsified to produce nanofat, which was then combined with PRF to create a Nanofat-PRF membrane. The resulting membrane was uniform, versatile, and suture-friendly, making it ideal for various medical and surgical applications. Between April 2019 and April 2024, 172 patients received treatment using a nanofat membrane. The membrane showed significant improvement in wound healing in various cases including diabetic foot ulcers, cleft palate surgeries, facial dermabrasion, skin necrosis, revision rhinoplasties, and post-cosmetic surgery complications. Postoperative follow-up after healing ranged from 1 to 16 months, showing high patient satisfaction and significant improvements in wound healing and no reported complications. The nanofat membrane presents a versatile and innovative approach to enhancing healing across a broad range of medical and surgical applic

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Early human evidence such as case series or small samples, often without a control group.

How we grade evidence
HumansWound HealingFemaleMaleMiddle AgedAdultAdipose TissuePlatelet-Rich FibrinTreatment OutcomeAged
Face & SkinAnkle & FootDiabetic FootChronic Wound
View on PubMedDOI

Related research