SVF
Level D· Preclinical EvidenceLaboratory Study

Regenerative therapies for complex diabetic foot wounds: a therapeutic challenge.

Grillo VTRDS., Romio EA., Sousa CD., Ranite GG., da Silva WR., Melluci PL.

Laboratory Study on Diabetic Foot, Chronic Wound, published in J Vasc Bras (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Laboratory Study
Journal
J Vasc Bras (2026)
Country
Brazil
Reported sample size
—
PMID
42094715
DOI
10.1590/1677-5449.202500712

Abstract (original English)

Diabetic foot ulcers are a leading cause of morbidity, hospitalization, and nontraumatic lower-extremity amputation in patients with diabetes mellitus. Effective management of these wounds requires a multidisciplinary approach and combined therapies addressing infection control, perfusion optimization, and stimulation of tissue regeneration. This case report describes a patient with a severe infected neuroischemic foot ulcer treated with a sequential integrated strategy: infrapatellar endovascular revascularization, targeted antibiotic therapy, serial debridement, negative pressure wound therapy, application of an ovine-derived extracellular matrix, and autologous grafting of adipose tissue-derived mesenchymal stem cells. The treatment resulted in complete wound healing and limb preservation, with no recurrence after 7 months of follow-up. This case highlights the potential role of advanced regenerative therapies in the management of complex, refractory diabetic foot wounds, expanding therapeutic perspectives in the care of patients with diabetic foot. As úlceras do pé diabético representam uma das principais causas de morbidade, hospitalização e amputação não traumática de membros inferiores em pacientes com diabetes melito. O manejo eficaz dessas lesões requer abordagem multidisciplinar e terapias combinadas que contemplem controle infeccioso, otimização da perfusão e estímul

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence comes from animal or laboratory studies and has not been confirmed in humans.

How we grade evidence
KneeAnkle & FootSystemic / IVDiabetic FootChronic Wound
View on PubMedDOI

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