[Research advances on exosomes derived from adipose-derived mesenchymal stem cells in promoting diabetic wound healing].

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Impaired healing of diabetic wounds is mainly attributed to its pathological mechanism, and refractory diabetic wounds bring heavy burdens to patients and society. Exosomes derived from stem cells possess the similar ability as stem cells in promoting tissue regeneration and more clinical advantages and are gradually playing important roles in wound healing. In recent years, researches have shown that exosomes derived from adipose-derived mesenchymal stem cells (ADSC-EXOs) can promote the healing of diabetic wounds by participating in various processes of wound healing. This article reviews the pathological mechanism leading to impaired healing of diabetic wounds, the related mechanism and the application prospect of ADSC-EXOs in promoting diabetic wound healing. 糖尿病创面形成的病理机制是导致糖尿病创面愈合困难的重要原因之一，难愈的糖尿病创面为患者及社会带来沉重负担。来源于干细胞的外泌体具有与干细胞相似的促组织再生能力及更多的临床优势，逐渐在创面愈合中发挥重要作用。近年来，诸多研究显示，脂肪间充质干细胞外泌体（ADSC-EXO）通过参与糖尿病创面愈合的各个过程，促进创面愈合。该文就导致糖尿病创面愈合困难的病理机制、ADSC-EXO促进糖尿病创面愈合的相关作用机制及其应用前景进行综述。.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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