Systematic Review of Stem Cells in Plastic, Reconstructive, and Aesthetic Surgery: Clinical Application in Anti-Aging Medicine.
Napoleon H., Djohan PB., Evelyn E., Lypinsky L., Luziani S., Margaretha MC.
Systematic Review on Cartilage Damage, Chronic Wound, Scar, Facial Rejuvenation, published in Indian J Plast Surg (2026) — summary generated from the PubMed abstract.
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Systematic Review
- Journal
- Indian J Plast Surg (2026)
- Country
- Germany
- Reported sample size
- —
- PMID
- 42344566
- DOI
- 10.1055/s-0045-1812020
Abstract (original English)
The application of stem cells in plastic, reconstructive, and aesthetic surgery has emerged as a promising frontier in anti-aging medicine. Stem cells, particularly adipose-derived stem cells (ADSCs) and mesenchymal stem cells (MSCs), are increasingly utilized for their regenerative properties, offering innovative solutions for a range of aesthetic and reconstructive challenges. This review explores the current and potential clinical applications of stem cells in plastic surgery, focusing on their role in grafting, facial rejuvenation, wound healing, soft tissue reconstruction, and hair restoration. A comprehensive literature analysis was conducted using the PRISMA algorithm, examining studies and clinical trials that evaluate the efficacy, safety, and outcomes of stem cell-based therapies in plastic surgery. Emphasis was placed on the therapeutic mechanisms of stem cells, including their ability to enhance tissue regeneration, reduce scarring, and improve graft survival. Out of the 5,117 studies identified, 22 met the inclusion criteria, highlighting the diverse applications of stem cells in plastic surgery. These studies reported significant advancements in aesthetic and reconstructive outcomes. Stem cell therapies represent a transformative approach in plastic surgery, offering significant benefits in aesthetic enhancement and functional restoration. While current applicatio
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
How we grade evidenceRelated research
- Level ASystematic Review
A Systematic Review on Amnion as a Cell Delivery Scaffolding Material for Cartilage Regeneration in Pre-Clinical and Clinical Studies.
Systematic Review on Osteoarthritis, Cartilage Damage, published in Bioengineering (Basel) (2026) — summary generated from the PubMed abstract.
- 2026
Bioengineering (Basel) - Level ASystematic Review
Intra-articular adipose-derived cell therapies for knee osteoarthritis: a systematic review of randomized controlled trials.
Systematic Review on Knee Osteoarthritis, Osteoarthritis, Cartilage Damage, published in Front Med (Lausanne) (2026) — summary generated from the PubMed abstract.
- 2026
Front Med (Lausanne) - Level ASystematic Review
A Comparison of the Properties of Mesenchymal Stem Cells Derived from Different Synovial Sources: A Systematic Review.
Systematic Review on Osteoarthritis, Cartilage Damage, published in Int J Mol Sci (2026) — summary generated from the PubMed abstract.
- 2026
Int J Mol Sci - Level ASystematic Review
A Systematic Review and Meta-Analysis of Regenerative Therapies for Hip Cartilage Lesions and Their Outcomes.
Systematic Review with a reported sample of 1059 on Osteoarthritis, Cartilage Damage, published in Hip Int (2026) — summary generated from the PubMed abstract.
- 2026
- n = 1059
Hip Int - Level ARandomized Controlled Trial
Intra-articular Orthobiologics Show Statistically but Not Clinically Meaningful Improvements Compared With Viscosupplementation in Knee Osteoarthritis: A Network Meta-analysis of Randomized Controlled Trials.
Randomized Controlled Trial with a reported sample of 2960 on Knee Osteoarthritis, Osteoarthritis, Cartilage Damage, published in Arthroscopy (2026) — summary generated from the PubMed abstract.
- 2026
- n = 2960
Arthroscopy - Level ASystematic Review
Coculture of Chondrocytes and Stem Cells: A Review of Head and Neck Cell Lines for Cartilage Regeneration.
Systematic Review with a reported sample of 10 on Osteoarthritis, Cartilage Damage, published in Cells Tissues Organs (2025) — summary generated from the PubMed abstract.
- 2025
- n = 10
Cells Tissues Organs