Systematic Review of Stem Cells in Plastic, Reconstructive, and Aesthetic Surgery: Clinical Application in Anti-Aging Medicine.

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background The application of stem cells in plastic, reconstructive, and aesthetic surgery has emerged as a promising frontier in anti-aging medicine. Stem cells, particularly adipose-derived stem cells (ADSCs) and mesenchymal stem cells (MSCs), are increasingly utilized for their regenerative properties, offering innovative solutions for a range of aesthetic and reconstructive challenges. Objective This review explores the current and potential clinical applications of stem cells in plastic surgery, focusing on their role in grafting, facial rejuvenation, wound healing, soft tissue reconstruction, and hair restoration. Materials and methods A comprehensive literature analysis was conducted using the PRISMA algorithm, examining studies and clinical trials that evaluate the efficacy, safety, and outcomes of stem cell-based therapies in plastic surgery. Emphasis was placed on the therapeutic mechanisms of stem cells, including their ability to enhance tissue regeneration, reduce scarring, and improve graft survival. Results Out of the 5,117 studies identified, 22 met the inclusion criteria, highlighting the diverse applications of stem cells in plastic surgery. These studies reported significant advancements in aesthetic and reconstructive outcomes. Conclusion Stem cell therapies represent a transformative approach in plastic surgery, offering significant benefits in aesthetic en

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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