TEAD1 Enhances Exosome Secretion and Promotes Exosome-Mediated Tissue Regeneration.
Pu Y., Wan Y., Shi W., Li B., Zhang H., Wu J.
Animal Study on Diabetic Foot, Spinal Cord Injury, Chronic Wound, published in Adv Sci (Weinh) (2026) — summary generated from the PubMed abstract.
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Adv Sci (Weinh) (2026)
- Country
- Germany
- Reported sample size
- —
- PMID
- 41815094
- DOI
- 10.1002/advs.202514104
Abstract (original English)
Exosomes serve as intercellular communication vectors and are involved in a broad range of physiological functions. Although exosome-based therapies have demonstrated diverse functional potential, the regulatory mechanisms underlying their biogenesis and secretion remain poorly understood. Here, we report that TEAD1 functions as a molecular switch, dramatically enhancing the synthesis and secretion of exosomes. Mechanistically, TEAD1 enhances exosome secretion by promoting the expression of exosome secretion-associated proteins RAB11, CD9, and SNAP23. We found that TEAD1 enhances exosome secretion from adipose-derived mesenchymal stem cells, thereby promoting skin wound healing in diabetic mice. Similarly, TEAD1 promotes the release of exosomes from bone marrow-derived mesenchymal stem cells, thereby facilitating spinal cord injury (SCI) repair. Our study elucidates a novel role for TEAD1 in driving exosome secretion in different cell types, highlighting the therapeutic potential of TEAD1 in enhancing tissue regeneration, particularly in diabetic wound healing and SCI repair.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence comes from animal or laboratory studies and has not been confirmed in humans.
How we grade evidenceRelated research
- Level AMeta-analysis
Therapeutic Effect of Stem Cells from Different Sources on Diabetic Foot Ulcers: Systematic Review and Network Meta-Analysis.
Meta-analysis on Ankle Injury, Diabetic Foot, Chronic Wound, published in Int J Low Extrem Wounds (2026) — summary generated from the PubMed abstract.
- 2026
Int J Low Extrem Wounds - Level AMeta-analysis
Efficacy of Stem Cell-Derived Exosomes in Promoting Diabetic Foot Ulcer Healing: A Meta-Analysis of Preclinical Animal Studies.
Meta-analysis on Diabetic Foot, Chronic Wound, published in J Diabetes Res (2026) — summary generated from the PubMed abstract.
- 2026
J Diabetes Res - Level AMeta-analysis
Role of Adipose Derived Stem Cells in Patients with Diabetic Foot Ulcers: Systematic Review and Meta-Analysis of Randomised Controlled Trials.
Meta-analysis with a reported sample of 81 on Diabetic Foot, Chronic Wound, published in Int J Low Extrem Wounds (2025) — summary generated from the PubMed abstract.
- 2025
- n = 81
Int J Low Extrem Wounds - Level ASystematic Review
Therapeutic potential of adipose-derived stem cells for diabetic foot ulcers: a systematic review and meta-analysis.
Systematic Review on Diabetic Foot, Chronic Wound, published in Diabetol Metab Syndr (2025) — summary generated from the PubMed abstract.
- 2025
Diabetol Metab Syndr - Level AMeta-analysis
A meta-analysis on application and prospect of cell therapy in the treatment of diabetes mellitus.
Meta-analysis on Diabetic Foot, Autoimmune Research, published in Stem Cell Res Ther (2025) — summary generated from the PubMed abstract.
- 2025
Stem Cell Res Ther - Level ASystematic Review
Effects of Nanofat in Plastic and Reconstructive Surgery: A Systematic Review.
Systematic Review with a reported sample of 253 on Diabetic Foot, Chronic Wound, Scar, Skin Aging, published in Plast Reconstr Surg (2024) — summary generated from the PubMed abstract.
- 2024
- n = 253
Plast Reconstr Surg