Clinical trial
Intra-articular SVF Injection in Moderate Knee Osteoarthritis
Single autologous adipose-derived SVF injection versus saline.
A registered trial means this question is still being studied. It is not evidence that the treatment works or is approved.
- Registry ID
- NCT05123456
- Status
- Recruiting
- Phase
- Phase 2
- Sponsor
- Mahidol University
- Country
- Thailand
- Enrollment
- 120
- Study design
- Randomized, double-blind, controlled
- Start date
- 2024-06-01
- Est. completion
- 2027-05-31
- Last updated
- 2026-05-12
Inclusion criteria
- • Age 45–75 years
- • Knee OA Kellgren-Lawrence grade 2–3
Exclusion criteria
- • Prior knee replacement
- • Active joint infection
Related published research
Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial
A multicentre randomized trial in 480 knee osteoarthritis patients comparing SVF, BMAC and umbilical cord MSCs against corticosteroid injection. At 12 months no cell product outperformed the steroid control.
- 2023
- United States
- n = 480
Intra-articular Injection of Autologous Adipose-Derived Stem Cells or Stromal Vascular Fractions: Are They Effective for Patients With Knee Osteoarthritis? A Systematic Review With Meta-analysis of Randomized Controlled Trials
Pooled five RCTs comparing ADSC/SVF injection with placebo or hyaluronic acid, finding significant pain and function improvement at 6 and 12 months.
- 2023
- South Korea
Rapid-acting pain relief in knee osteoarthritis: autologous-cultured adipose-derived mesenchymal stem cells outperform stromal vascular fraction: a systematic review and meta-analysis
Analysed 31 studies with 1,406 patients: cultured ADMSCs reduced pain from month 3, whereas SVF reached significance only at 12 months.
- 2024
- South Korea
- n = 1406
Clinical Efficacy of Bone Marrow Aspirate Concentrate Versus Stromal Vascular Fraction Injection in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis
Synthesised clinical studies of a single intra-articular BMAC or SVF injection to compare effect sizes for pain and function.
- 2022
- United States